Location: SR 161 and SR 66, Reo, Spencer Cty Reassurance shield as 161 splits. Location: SR 161 and Old SR 45, Spencer Cty Reassurance shield a couple miles later as we cross an old state road. Location: SR 161 and KY-2262, Spencer Cty Before we cross the Ohio River, we’re welcomed to Kentucky! KYTC maintains … Continue reading Indiana State Road 161, IN-66 to KY-2262/KY State Line